Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Susceptibility Studies
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چکیده
منابع مشابه
Cefoxitin, a semisynthetic cephamycin antibiotic: susceptibility studies.
Cefoxitin, 3-carbamoyloxymethyl-7-alpha-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4- carboxylic acid, is a new semisynthetic cephamycin with broad antibacterial activity. It is highly active against gram-negative microorganisms including indole-positive Proteus and Serratia strains, which are ordinarily reistant to the cephalosporins. Cefoxitin is also highly active against many strains of Es...
متن کاملCefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation.
Cefoxitin is a new, cephalosporin-like antibiotic which is highly resistant to hydrolysis by beta-lactamase. Ninety-one cultures were selected either for their general resistance to cephalosporin antibiotics or for their ability to produce beta-lactamase. Some of these cultures were resistant to cefoxitin. The capacity of each of the 91 strains to hydrolyze cefoxitin with beta-lactamase was det...
متن کاملCefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.
The in vitro activity of cefoxitin, 3-carbamolyloxymethyl-7-alpha-methoxy-7[2-(2-thienyl)acetamido]-3-cephem-4-carboyxlic acid, was investigated. Activity against gram-positive organisms was less than that of cephalothin and cephloridine. It was highly active against gram-negative bacilli, with activity against Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae equal to that of curr...
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BB-K 8, a new semisynthetic aminoglycosidic antibiotic, was evaluated for ototoxicity, nephrotoxicity and neuromuscular blocking activity in the cat. As a reference, kanamycin was tested by the same experimental methods. Employing equivalent doses in terms of the free base and 7 days of intraperitoneal treatment, BB-K8 and kanamycin were found to be similarly ototoxic and nephrotoxic. Acutely, ...
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as celesticetin2) (2) have been prepared3) by synthetic anc microbiological transformation, involving modificatior of the parent antibiotics both at the sugar moiety anc the amino acid side-chain (Fig. 1). Of these new derivatives 7(S)-chloro-7-deoxylincomycin4) (3, cleocin, clindamycin) is one of the most important, possessing mon pronounced and wider spectrum of antibiotic activity, a* well a...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1974
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.5.1.25